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Compound Research SpotlightsIntermediate

MOTS-c Compound Spotlight

Molecular and handling-oriented profile for MOTS-c: sequence context, formula/mass references, appearance, solubility framing, and storage characteristics for research materials.

Last reviewed: September 22, 2026

MOTS-c

Scope of this spotlight

This page consolidates molecular characteristics and laboratory handling notes for MOTS-c research material. It intentionally omits proposed research applications, dosing, administration routes, and outcome claims.

Compound data card

MOTS-c

Sequence (single-letter)
MRWQEMGYIFYPRKLR
Molecular formula
C101H152N28O22S2 (illustrative free base framing — confirm salt form on COA)
Molecular weight
~2174.6 Da (verify lot-specific MS / calculation)
Physical appearance
White to off-white lyophilized powder (typical)
Solubility profile
Often approached in aqueous systems; confirm solvent system against COA / method needs
Preferred storage (dry)
Sealed, protected from moisture; commonly −20°C for long-term holds
Reconstituted hold
Define validated hold time in your SOP; minimize freeze–thaw cycles

Identity anchors

Laboratory identity checks typically combine:

  • Sequence / formula documentation from the supplier
  • Observed mass consistent with the expected Dalton value
  • Chromatographic purity consistent with the COA method

Expected Da

2174.60

Observed Da

2174.55

Delta

-0.05

MOTS-c (illustrative): Within typical identity window

Stability & handling characteristics

Like many lyophilized peptides, MOTS-c research lots are generally more stable in the dry, sealed state than after reconstitution. Practical laboratory controls include:

  • Limit light and humidity exposure when vials are open
  • Avoid aggressive mechanical shear during dissolution
  • Document storage location, temperature logger IDs, and open dates
Handling-oriented storage framing for lyophilized MOTS-c lots
ConditionMax recommended durationStability notesStatus
−20°C, sealedPer COA datingPreferred archive condition for dry cake when validated by the supplier statement.Recommended
2–8°C, sealedShort stagingInterim refrigeration may be used when SOPs allow brief staging before reconstitution.Limited
Ambient, open vialAvoid prolongedHumidity and contamination risk rise once the seal is broken.Not preferred

Incoming MOTS-c lot checks

Expansion note

Additional compound spotlights (BPC-157, TB-500, and others from the catalog) should reuse this template: sequence/formula, mass, appearance, solubility, stability framing, and storage handling — sourced from primary literature and analytical documentation, not competitor blog copy.

Sources & references

  1. Primary literature describing the MOTS-c peptide sequence and mitochondrial ORF context (PubMed/NCBI indexed).
  2. Manufacturer and analytical lab technical sheets for lyophilized peptide molecular weight and appearance conventions.
  3. General peptide solubility and cold-storage handling references (pharmacopeial / lyophilization handbooks).

Citations support factual claims about handling, analytical methods, and molecular characteristics. Have counsel review disclaimer copy before publication.